Infection Centre

Research & Trials

Home › Research & Trials

Research

Study Evaluating the Safety, Immunogenicity and Tolerability of Meningococcal Group B Vaccine in Healthy Adults

10 Aug 2007
To determine the safety & immunogenicity of a potential vaccine against meningococcal B disease › More

A Study of GT267-004 Versus Vancomycin and GT267-004 Versus Metronidazole in Patients With C. Difficile-Associated Diarrhea

9 Aug 2007
This study aims to determine if an investigational drug is safe and effective for treating symptoms of C. difficile-associated diarrhea (CDAD) and lowering the risk of repeat episodes of CDAD. The ... › More

Safety Study of Herpes Simplex Vaccine in HSV Seronegative and Seropositive Females Between 10 and 17 Years Old

23 Jul 2007
Main goal of this study is to compare the occurrence of serious adverse events (SAEs) between the herpes simplex (gD2-AS04) vaccine group and the Saline control group throughout the study period (up ... › More

Study to Evaluate the Efficacy of the Human Papillomavirus Vaccine in Healthy Adult Women of 26 Years of Age and Older.

26 Jun 2007
This study will evaluate the immune responses, safety and efficacy of the investigational HPV vaccine in women who are 26 years of age or older. Infection with human papilloma virus (HPV) has been ... › More

Clinical Utility Of Genetic Screening For HLA-B*5701, On Susceptibility To Drug Hypersensitivity

16 Jun 2007
Study to evaluate the utility of prospective HLA-B*5701 screening on the incidence of abacavir hypersensitivity (ABC HSR) in 1800 previously ABC-naive adults with HIV-1 from Europe, Australia and ... › More

Super High-Flux - High Volume Dialysis in Sepsis-Induced Acute Renal Failure

17 May 2007
We wish to compare the effect of using new large hole filters with hemodialysis in patients with severe infections and acute kidney failure to that of standard filters. The new therapy will be ... › More

Hib-MenCY-TT Vaccine Study Compared to Licensed Hib and Meningococcal Serogroup C Conjugate Vaccines

11 May 2007
This study is evaluating the safety and immunogenicity of Hib-MenCY-TT vaccine compared to control groups receiving licensed Hib or MenC conjugate vaccines, each administered at 2, 4, 6, and 12 to 15 ... › More

The Pharmacokinetics of Double Boosted Protease Inhibitors in Antiretroviral-Naive HIV-1 Infected Patients

29 Apr 2007
Treatment with only protease inhibitors might benefit HIV patients. Laboratory data have shown that the combination of saquinavir with lopinavir and ritonavir may a good regimen. This study will ... › More

Study of a Pandemic Influenza Vaccine in healthy adults

14 Mar 2007
The avian influenza H5N1 virus strain is the leading candidate to cause the next avian influenza pandemic. This study will test the safety and immunogenicity of a H5N1 pandemic influenza vaccine in ... › More

Trials

Isavuconazole in the Treatment of Candidemia and Other Invasive Candida Infections

3 Sep 2007
The purpose of the study is to compare the safety and efficacy of Isavuconazole versus caspofungin followed by voriconazole in the treatment of candidemia and other invasive Candida infections. › More

Safety Study of Oral BTA9881 to Treat Respiratory Syncytial Virus Infections

28 Aug 2007
This is a placebo-controlled, double-blind, randomised, single dose escalation Phase I clinical trial to determine the safety and tolerability of BTA9881 administered orally to healthy subjects. › More

Venticute in Patients With Pneumonia or Aspiration of Gastric Contents and Intubation/Ventilation/Oxygenation Impairment

20 Jun 2007
Study to demonstrate that administration of Venticute increases survival of patients with pneumonia or aspiration of gastric contents leading to intubation, mechanical ventilation, and severe ... › More

Study Evaluating Safety & Immunogenicity of rLP2086 Meningitis Vaccine in Adolescents

8 Jun 2007
Study to evaluate the safety of an investigational meningitis vaccine and the immune response to it in adolescents › More

Predictors of Drug Hypersensitivity in HIV Infected Subjects

5 Jun 2007
A case-control study to look at hypersensitive and tolerant individuals matched for HLA genetic predisposition, when considering predictors of drug hypersensitivity.The study aims to identify the ... › More

A Study to Evaluate the Efficacy, Safety, and Tolerability of TAK-583 in Subjects With Postherpetic Neuralgia (PHN)

31 May 2007
The purpose of the study is to assess the safety and ability of TAK-583 to relieve pain in subjects with PHN, compared with placebo. › More

Study Evaluating the Safety and Efficacy of a Once-Daily Dose of Tigecycline vs Ertapenem in Diabetic Foot Infections with Osteomyelitus

31 May 2007
This purpose of this study is to look at the safety and effectiveness of a once-daily dose of tigecycline compared to ertapenem for the treatment of diabetic foot infections with osteomyelitis. › More

Antiviral Activity of Entecavir in Patients Receiving Liver Transplant Due to Chronic Hepatitis B Virus Infection

17 May 2007
The purpose of this clinical research study is to learn if the study drug entecavir will prevent the recurrence of hepatitis B virus in subjects who receive an orthotopic liver transplant (OLT). › More

Study Comparing Tigecycline Versus Ceftriaxone Sodium Plus Metronidazole in Complicated Intra-Abdominal Infection (cIAI)

2 May 2007
This is a study of the safety and efficacy of tigecycline to ceftriaxone sodium plus metronidazole in hospitalized subjects with cIAI. Subjects will be followed for efficacy through the test-of-cure ... › More

Pneumococcal Vaccination of Australian Indigenous Mothers to See If It Protects Their Babies From Ear Disease

12 Apr 2007
PneuMum is a randomised controlled trial that aims to find out if pneumococcal vaccination for Australian Indigenous mothers, in the last few months of pregnancy or at delivery, can prevent ear ... › More

The support of the following commercial entities are greatfully acknowledged: